Conference Day One
7:45 am Registration & Morning Coffee
8:15 am Chair’s Opening Remarks
Realizing the Potential of Synthetic Biology to Reshape Biological Systems
8:30 am Industry Leader’s Panel: Identifying Target Markets & Applications for Synthetic Biology Therapies
Synopsis
- Insights from industry leaders on last year’s progress and market opportunities
- Strategies for selecting the most promising therapeutic applications for synthetic biology
- Understanding patient needs and market demands for effective product development
9:00 am Employing Logic Gating for Enhanced Specificity & Therapeutic Design
Synopsis
- Harnessing logic gating to improve targeting and control in synthetic biology systems
- Understanding the uses of OR and AND gating for more specific therapeutic outcomes
- Optimizing the design and functionality of synthetic gene circuits using logic gating
9:30 am Integrated Circuit T-Cells for the Treatment of Solid Tumors
Synopsis
- Improving anti-tumor specificity using logic gating
- Enhancing T-cell effector function through loss- and gain-of-function augmentation
- Engineering T-cells to resist TME suppression
10:00 am Morning Break & Speed Networking
Synopsis
As this community reunites, this session will provide valuable networking time with your peers, enabling you to forge new and lasting connections
Increasing Targeting & Specificity for Safer Gene Editing
11:00 am Panel: Re-evaluating Delivery Vehicle Mechanisms for Enhanced Safety & Efficiency
Synopsis
- Evaluating the pros and cons of different delivery methods: engineered bacteria, LNP, viral vectors, HSV
- Assessing their safety profiles and impact on gene editing efficiency
- Highlighting the varying suitability of delivery technologies for improved specificity and reduced off-target effects
11:30 am Translating In Vivo Gene Editing to Microbiome Targets
Synopsis
- Expanding the range of disease targets to bacterial genes
- Engineering of non-replicative viral vectors to deliver large payloads to the microbiome
- Achieving high efficiency in situ editing
12:00 pm Lunch
Computational Tools & AI for Intentional Therapeutic Design
1:00 pm Harnessing Computational Protein Engineering & Structural Modeling for Intentional Therapeutic Design
Synopsis
- Harnessing computational tools for protein engineering in synthetic biology-based therapies
- Modeling protein structures to assess stability, immunogenicity, binding affinity, solubility and expression levels
- Free energy calculation computational approach for rational design and optimization of synthetic proteins
1:30 pm Roundtable: Integrating Sequence- & Structure-Based AI Approaches to Enhance Protein Engineering
Synopsis
- Machine learning/AI approaches now enable useful functional information to be extracted from protein sequence data at a level greater than ever before possible
- Structure prediction, now also increasingly incorporating machine learning/AI, is achieving unprecedented levels of accuracy, making actionable predictions readily available for many applications
- Sequence- and structure-based approaches can complement each other, and finding new ways to integrate them may enable even more powerful new approaches to protein engineering
2:30 pm Afternoon Break & Networking
3:30 pm AI Assisted DNA Synthesis to Enhance Gene Therapy
Synopsis
- Delve into the synergy between AI and HSV as a powerful platform for targeted gene delivery
- Understand how AI-guided DNA synthesis is optimizing viral vectors to enhance their specificity, efficiency, and safety in gene therapy applications
- Explore the potential of AI-assisted DNA synthesis to design patient-specific gene constructs that effectively address a wide array of genetic disorders
Reprogramming with Synthetic Biology for Increased Precision
4:00 pm Engineering Antibody-Based Molecules that Reshape Immune Cell Behavior for Targeted Treatment of Cancer
Synopsis
- Cytokine/anti-cytokine antibody fusion proteins (immunocytokines) selectively deliver cytokines to particular immune cell subsets through distinct structural and molecular effects
- Immunocytokines promote effector-T and natural killer cell expansion to mount potent antitumor effects
- Tumor-targeted delivery of immunocytokines improves safety and efficacy of cancer treatment regimens
4:30 pm Sensing Intra- & Extracellular States Using RNA Editing
Synopsis
- Programmable sensing for mRNA transcripts
- Next-gen sensor design with broader input-compatibility
- Modular synthetic receptor for extracellular ligands